Article
Behavioral screening defines the molecular Parkinsonism-related subgroups in Drosophila.
Nature communications - 10 Mar 2026
Kaempf Natalie, Valadas Jorge S, Robberechts Pieter, Schoovaerts Nils, Praschberger Roman, Ortega Antonio, Nachman Eliana, Ghezzi Lorenzo, Kilic Ayse, Chabot Dries, Pech Uli, Kuenen Sabine, Vilain Sven, Baz El-Sayed, Singh Jeevanjot, Davis Jesse, Liu Sha, Verstreken Patrik
Abstract excerpt
Parkinson's disease (PD) and related familial Parkinsonism are defined by motor dysfunction, but the specific upstream molecular causes of these clinical symptoms can vary widely. We hypothesize that these causes converge onto a limited number of core cellular pathways. To investigate this, we created a collection of 24 genetically well-controlled Drosophila models of familial forms of PD and related mono-genic...
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