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Article

Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.

Human molecular genetics - 4 May 2024

Nithianandam Vanitha, Sarkar Souvarish, Feany Mel B

Abstract excerpt

Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are common, severe and untreatable. We recovered a number of mitochondrial genes, including electron transport chain components, in a large forward genetic screen for mutations causing age-related neurodegeneration in the context of proteostasis dysfunction. We created a model of complex I deficiency in the Drosophila retina to...

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Identifiers

PMID: 38324746
DOI: 10.1093/hmg/ddae018
PMCID: PMC11070137

Genes

RIOK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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