Article

Hypercholesterolemia risk associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol level in human and mouse

2020-01-10

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with dyslipidemia. However, about 95% of of these variants are located in genome noncoding regions and cluster in different loci. The disease-causing variant for each locus and underline mechanism remain largely unknown. We systematically analyzed these noncoding variants and found that rs1997243 is the disease-causing v...

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Literature Corpus work: e03ef2d9-69e2-5361-8bd5-7d8efb8f1c65
DOI: 10.1101/2020.01.09.901041

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