Article

Rare pathogenic variants in G-protein coupled receptor genes involved in gut-to- host communication are associated with cardiovascular disease risk

2024-10-02

Abstract excerpt

<h4>Background</h4> Gut microbial metabolites called short-chain fatty acids (SCFA) confer protective effects against cardiovascular disease and high blood pressure. Proposed mechanisms include anti-inflammatory signalling mediated by SCFA-sensing G-protein-coupled receptors (GPCR), particularly GPR41, GPR43, and GPR109a, as suggested by knockout mouse models. We aimed to determine if rare pathogenic variants (RPV...

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Literature Corpus work: fe0fc6b8-b73c-5920-a6d2-6a15994ab5be
DOI: 10.1101/2024.10.01.24314734

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