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Article

The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis.

The Journal of clinical investigation - 2 Sept 2025

Durumutla Hima Bindu, Haller April, Noble Greta, Prabakaran Ashok Daniel, McFarland Kevin, Latimer Hannah, Rajput Akanksha, Akinborewa Olukunle, Namjou-Khales Bahram, Hui David Y, Quattrocelli Mattia

Abstract excerpt

Elevated cholesterol poses cardiovascular risks. The glucocorticoid receptor (GR) harbors a still undefined role in cholesterol regulation. Here, we report that a coding SNP in the gene encoding the GR, rs6190, is associated with increased cholesterol in women according to UK Biobank and All of Us (NIH) datasets. In SNP-genocopying mice, we found that the SNP enhanced hepatic GR activity to transactivate Pcsk9...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40591411
DOI: 10.1172/JCI190180
PMCID: PMC12404749

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