Article
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
PLoS genetics - 1 Oct 2011
Surakka Ida, Isaacs Aaron, Karssen Lennart C, Laurila Pirkka-Pekka P, Middelberg Rita P S, Tikkanen Emmi, Ried Janina S, Lamina Claudia, Mangino Massimo, Igl Wilmar, Hottenga Jouke-Jan, Lagou Vasiliki, van der Harst Pim, Mateo Leach Irene, Esko Tõnu, Kutalik Zoltán, Wainwright Nicholas W, Struchalin Maksim V, Sarin Antti-Pekka, Kangas Antti J, Viikari Jorma S, Perola Markus, Rantanen Taina, Petersen Ann-Kristin, Soininen Pasi, Johansson Asa, Soranzo Nicole, Heath Andrew C, Papamarkou Theodore, Prokopenko Inga, Tönjes Anke, Kronenberg Florian, Döring Angela, Rivadeneira Fernando, Montgomery Grant W, Whitfield John B, Kähönen Mika, Lehtimäki Terho, Freimer Nelson B, Willemsen Gonneke, de Geus Eco J C, Palotie Aarno, Sandhu Manj S, Waterworth Dawn M, Metspalu Andres, Stumvoll Michael, Uitterlinden André G, Jula Antti, Navis Gerjan, Wijmenga Cisca, Wolffenbuttel Bruce H R, Taskinen Marja-Riitta, Ala-Korpela Mika, Kaprio Jaakko, Kyvik Kirsten O, Boomsma Dorret I, Pedersen Nancy L, Gyllensten Ulf, Wilson James F, Rudan Igor, Campbell Harry, Pramstaller Peter P, Spector Tim D, Witteman Jacqueline C M, Eriksson Johan G, Salomaa Veikko, Oostra Ben A, Raitakari Olli T, Wichmann H-Erich, Gieger Christian, Järvelin Marjo-Riitta, Martin Nicholas G, Hofman Albert, McCarthy Mark I, Peltonen Leena, van Duijn Cornelia M, Aulchenko Yurii S, Ripatti Samuli
Abstract excerpt
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a...
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