Article
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.
Nature medicine - 1 Nov 2015
Wagschal Alexandre, Najafi-Shoushtari S Hani, Wang Lifeng, Goedeke Leigh, Sinha Sumita, deLemos Andrew S, Black Josh C, Ramírez Cristina M, Li Yingxia, Tewhey Ryan, Hatoum Ida, Shah Naisha, Lu Yong, Kristo Fjoralba, Psychogios Nikolaos, Vrbanac Vladimir, Lu Yi-Chien, Hla Timothy, de Cabo Rafael, Tsang John S, Schadt Eric, Sabeti Pardis C, Kathiresan Sekar, Cohen David E, Whetstine Johnathan, Chung Raymond T, Fernández-Hernando Carlos, Kaplan Lee M, Bernards Andre, Gerszten Robert E, Näär Anders M
Abstract excerpt
Genome-wide association studies (GWASs) have linked genes to various pathological traits. However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to pathological conditions has remained unclear. We leveraged GWAS meta-analysis data from >188,000 individuals to identify 69 miRNAs in physical proximity to single-nucleotide polymorphisms (SNPs)...
Topics
Join the communities discussing this publication.