Article
Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs.
Developmental biology - 15 Mar 2007
Iser Wendy B, Gami Minaxi S, Wolkow Catherine A
Abstract excerpt
In C. elegans, insulin signaling affects development, lifespan and stress resistance. Several studies have shown that insulin signaling affects lifespan in an endocrine-like manner from different cells, while the major downstream target of insulin, the FOXO transcription factor encoded by daf-16, may act preferentially in intestinal cells to prolong lifespan. This discrepancy raised the possibility that insulin...
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