An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.

doi:10.1371/journal.pgen.1004225

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Article

An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.

PLoS genetics - 1 Mar 2014

Fernandes de Abreu Diana Andrea, Caballero Antonio, Fardel Pascal, Stroustrup Nicholas, Chen Zhunan, Lee Kyunghwa, Keyes William D, Nash Zachary M, López-Moyado Isaac F, Vaggi Federico, Cornils Astrid, Regenass Martin, Neagu Anca, Ostojic Ivan, Liu Chang, Cho Yongmin, Sifoglu Deniz, Shen Yu, Fontana Walter, Lu Hang, Csikasz-Nagy Attila, Murphy Coleen T, Antebi Adam, Blanc Eric, Apfeld Javier, Zhang Yun, Alcedo Joy, Ch'ng Queelim

Abstract excerpt

Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phenotypes...

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PMID: 24675767
DOI: 10.1371/journal.pgen.1004225
PMCID: PMC3967928

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