Article

Epithelial stem cell-derived chemokines track clinical remission in inflammatory bowel disease in a disease-specific manner

2026-05-27

Abstract excerpt

<h4>Background and Aims</h4> Stem cell-derived organoids are promising platforms for therapeutic screening in inflammatory bowel disease (IBD), but identifying functional organoid readouts with translational utility is challenging. Colon epithelial organoids from patients with ulcerative colitis (UC) overexpress chemokines CXCL1, CXCL11, CCL2, and CCL28, yet whether these inflammatory signatures correlate with di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e03737f0-dfc1-58fb-9c2c-4384a40ed40d
DOI: 10.64898/2026.05.23.727433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial stem cell-derived chemokines track clinical remission in inflammatory bowel disease in a disease-specific mannerDOI 10.64898/2026.05.23.727433Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.Semantic proximity Read

Molecular characterization of response to etrolizumab and anti-TNF reveals treatment resistance in ulcerative colitis is associated with an abundance of residual neutrophil subsets and inflammatory fibroblast populationsSemantic proximity Read

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative ColitisSemantic proximity Read

A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized TherapeuticsSemantic proximity Read

New Approach Methodologies in Crohn’s Disease Link Molecular Disease Subtypes to Clinical OutcomesSemantic proximity Read

The Promise of Patient-Derived Colon Organoids to Model Ulcerative ColitisSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoidsSemantic proximity Read

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBDSemantic proximity Read

Biofabrication of primary patient tissue-derived inflammatory bowel disease (IBD) model by organoid three-dimensional cultureSemantic proximity Read

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.Semantic proximity Read