Article
Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.
Nature communications - 11 Jan 2021
Sarvestani Samaneh K, Signs Steven, Hu Bo, Yeu Yunku, Feng Hao, Ni Ying, Hill David R, Fisher Robert C, Ferrandon Sylvain, DeHaan Reece K, Stiene Jennifer, Cruise Michael, Hwang Tae Hyun, Shen Xiling, Spence Jason R, Huang Emina H
Abstract excerpt
The pathogenesis of ulcerative colitis (UC), a major type of inflammatory bowel disease, remains unknown. No model exists that adequately recapitulates the complexity of clinical UC. Here, we take advantage of induced pluripotent stem cells (iPSCs) to develop an induced human UC-derived organoid (iHUCO) model and compared it with the induced human normal organoid model (iHNO). Notably, iHUCOs recapitulated...
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