Article

Ablation of CXCR4 expression in cardiomyocytes exacerbates isoproterenol-induced cell death and heart failure

2022-08-03

Abstract excerpt

<title>Abstract</title> <p>Heart failure is an ageing-associated disease. CXCR4, a seven-transmembrane-spanning Gi-coupled receptor for the SDF-1 chemokine, plays a critical role in organogenesis, healthy ageing, vascular post-injury repair and regeneration; however, the specific role of cardiomyocyte CXCR4 in heart function and the pathogenesis of heart failure is incompletely understood. We hypothesize that CXC...

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Literature Corpus work: e02fe696-3089-543c-b6de-dd5ea8442d8a
DOI: 10.21203/rs.3.rs-1876305/v1

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