Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.

doi:10.1152/ajpheart.01061.2011

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Article

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2012

Montó Fermí, Oliver Eduardo, Vicente Diana, Rueda Joaquín, Agüero Jaime, Almenar Luis, Ivorra Maria Dolores, Barettino Domingo, D'Ocon Pilar

Abstract excerpt

Downregulation of β(1)- adrenergic receptors (β(1)-ARs) and increased expression/function of G-protein-coupled receptor kinase 2 (GRK2) have been observed in human heart failure, but changes in expression of other ARs and GRKs have not been established. Another unresolved question is the incidence of these compensatory mechanisms depending on heart failure etiology and treatment. To analyze these questions, we...

Topics

Adult
Analysis of Variance
Cardiomyopathies
Cardiomyopathy, Dilated
Female
G-Protein-Coupled Receptor Kinases
Genotype
Heart Failure
Humans
Linear Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Myocardial Ischemia

Myocardium

Phenotype

RNA, Messenger

Receptors, Adrenergic

Spain

Source

Open in PubMed

Identifiers

PMID: 22685168
DOI: 10.1152/ajpheart.01061.2011

Genes

GRK2
GRK3
GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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