Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression

Abstract excerpt

<title>Abstract</title> <p>Purpose The number of ischemic heart failure (HF) patients is growing dramatically worldwide. However, there are at present no preventive treatments for HF. Our previous study showed that Gata4 overexpression improved cardiac function after myocardial infarction in the rat heart. We also found that Gata4 overexpression significantly increased a Pnoc gene expression, an endogenous ligan...

Topics

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• Autophagy
• Disease Management
• Drug Delivery Systems
• Heart Failure
• Microbiota
• Myocytes, Cardiac
• Societies, Medical
• Translational Research, Biomedical

Identifiers and source

Literature Corpus work

0bc29c0c-df0c-53d4-bf59-3af27aae424f

DOI

10.21203/rs.3.rs-4578315/v1