Article

Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth

2020-06-09

Abstract excerpt

Primary cilia loss is a common feature of advanced cancers. While primary cilia are necessary to initiate Hedgehog (HH)-driven cancers, how HH pathway activity is maintained in advanced cancers devoid of primary cilia is unclear. Here, we find that HH-driven basal cell carcinoma (BCC) accumulates mutations in Alström and Usher syndrome genes. Loss of Alström and Usher syndrome gene expression, which are common und...

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Literature Corpus work: e019ef71-8387-5bf0-9472-55f4351ca0fb
DOI: 10.1101/2020.06.08.137216

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