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Article

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

Nature structural & molecular biology - 1 Jun 2010

Lauth Matthias, Bergström Asa, Shimokawa Takashi, Tostar Ulrica, Jin Qianren, Fendrich Volker, Guerra Carmen, Barbacid Mariano, Toftgård Rune

Abstract excerpt

Synergism between the RAS and Hedgehog (HH) pathways has been suggested for carcinogenesis in the pancreas, lung and colon. We investigated the molecular cross-talk between RAS and HH signaling and found that, although mutant RAS induces or enhances SHH expression and favors paracrine HH signalin...

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Source

Identifiers

PMID: 20512148
DOI: 10.1038/nsmb.1833

Genes

SHH
GLI1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20512148-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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