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Article

Loss of primary cilia occurs early in breast cancer development

1 Jul 2014

Abstract excerpt

BACKGROUND: Primary cilia are microtubule-based organelles that protrude from the cell surface. Primary cilia play a critical role in development and disease through regulation of signaling pathways including the Hedgehog pathway. Recent mouse models have also linked ciliary dysfunction to cancer. However, little is known about the role of primary cilia in breast cancer development. Primary cilia expression was...

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PMID: 24987519
DOI: 10.1186/2046-2530-3-7

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