Article

Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC

2024-05-10

Abstract excerpt

<title>Abstract</title> <p>Primary cilia are present on renal tubules and are implicated to play pivotal role in transducing signals during development; however, the oncogenic role of cilia in clear cell renal cell carcinoma (ccRCC) has not been examined. Here we show that VHL wild-type ccRCC cell lines have high incidence of primary cilia, and high frequency of primary cilia is positively correlated with VHL exp...

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Literature Corpus work: 38e2d066-3825-5f48-a2ed-358aeee89efb
DOI: 10.21203/rs.3.rs-4211121/v1

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Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCCDOI 10.21203/rs.3.rs-4211121/v1Read

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