Article
Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease.
Cell reports - 3 May 2022
Trieu Kenneth G, Tsai Shih-Ying, Eberl Markus, Ju Virginia, Ford Noah C, Doane Owen J, Peterson Jamie K, Veniaminova Natalia A, Grachtchouk Marina, Harms Paul W, Swartling Fredrik J, Dlugosz Andrzej A, Wong Sunny Y
Abstract excerpt
Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear. Here, we report that loss of Ptch1, the most common mutation that activates upstream Hedgehog (Hh) signaling, initiates the formation of nascent BCC-like tumors that eventually enter into a dormant state. However, rare tumors that overcome dormancy acquire...
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