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APOE4 carriers display loss of anticipatory cerebral vascular regulation over AD progression

2024-10-13

Abstract excerpt

<h4>INTRODUCTION</h4> Maintenance of cerebral blood flow during orthostasis is impaired with aging and associated with cognitive decline, but the effect of Apolipoprotein L4-allele ( APOE4 ) is unknown. <h4>METHODS</h4> Older adults (n=108) ( APOE4 carriers, n=47; noncarriers, n=61) diagnosed as cognitively-normal (NC), MCI, or AD participated. Middle cerebral artery blood velocity (MCAv), assessed using Transcran...

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Literature Corpus work
dfcddbe4-f475-5501-9e6f-888fc5bce489
DOI
10.1101/2024.10.11.24315344
Open publication

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APOE4 carriers display loss of anticipatory cerebral vascular regulation over AD progressionDOI 10.1101/2024.10.11.24315344
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