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Article

Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.

GeroScience - 1 Oct 2026

Potvin-Jutras Zacharie, Tremblay Pierre-Luc, Mohammadi Hanieh, Villeneuve Sylvia, Spreng R Nathan, Gauthier Claudine J

Abstract excerpt

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with aging and AD. However, the relationship between APOE4 status...

Read the complete abstract on PubMed

Topics

Humans
Female
Apolipoprotein E4
Cognition
Cerebrovascular Circulation
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Magnetic Resonance Imaging

Longitudinal Studies

Pulsatile Flow

Alzheimer Disease

Aging

Genotype

Vascular Stiffness

Source

Open in PubMed Open full text

Identifiers

PMID: 41353310
DOI: 10.1007/s11357-025-02036-3
PMCID: PMC13601492

Genes

CP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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