Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study.

doi:10.1177/0271678X211021313

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Article

Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 2021

Wang Rui, Oh Jennifer M, Motovylyak Alice, Ma Yue, Sager Mark A, Rowley Howard A, Johnson Kevin M, Gallagher Catherine L, Carlsson Cynthia M, Bendlin Barbara B, Johnson Sterling C, Asthana Sanjay, Eisenmenger Laura, Okonkwo Ozioma C

Abstract excerpt

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with...

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Identifiers

PMID: 34102919
DOI: 10.1177/0271678X211021313
PMCID: PMC8545048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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