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Article

APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2025

Palmer Jacqueline A, Kaufman Carolyn S, Whitaker-Hilbig Alicen A, Billinger Sandra A

Abstract excerpt

BACKGROUND: Maintenance of cerebral blood flow during orthostasis is impaired with aging and associated with cognitive decline, but the effect of the apolipoprotein ɛ4 allele (APOE4) is unknown. METHODS: Older adults (n = 108) (APOE4 carriers, n = 47; non-carriers, n = 61) diagnosed as having normal cognition (NC), mild cognitive impairment (MCI), or Alzheimer's disease (AD) underwent transcranial Doppler...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40346723
DOI: 10.1002/alz.70229
PMCID: PMC12064416

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