Article

VEFill: a model for accurate and generalizable deep mutational scanning score imputation across protein domains

2025-05-14

Abstract excerpt

<h4>Background</h4> Deep Mutational Scanning (DMS) assays can systematically assess the effects of amino acid substitutions on protein function. While DMS datasets have been generated for many targets, they often suffer from incomplete variant coverage due to technical constraints, limiting their utility in variant interpretation and downstream analyses. <h4>Results</h4> We developed VEFill, a gradient boosting...

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Literature Corpus work: 52d8dbf0-c0d1-5451-9ca7-aa6958309b73
DOI: 10.1101/2025.05.14.653991

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