Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation.

doi:10.1016/j.celrep.2021.110207

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Article

Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation.

Cell reports - 11 Jan 2022

Høie Magnus Haraldson, Cagiada Matteo, Beck Frederiksen Anders Haagen, Stein Amelie, Lindorff-Larsen Kresten

Abstract excerpt

Understanding and predicting the functional consequences of single amino acid changes is central in many areas of protein science. Here, we collect and analyze experimental measurements of effects of >150,000 variants in 29 proteins. We use biophysical calculations to predict changes in stability for each variant and assess them in light of sequence conservation. We find that the sequence analyses give more...

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