Article

Rapid protein stability prediction using deep learning representations

2022-07-15

Abstract excerpt

Predicting the thermodynamic stability of proteins is a common and widely used step in protein engineering, and when elucidating the molecular mechanisms behind evolution and disease. Here, we present RaSP, a method for making rapid and accurate predictions of changes in protein stability by leveraging deep learning representations. RaSP performs on-par with biophysics-based methods and enables saturation mutagene...

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Literature Corpus work: a3d4e763-ecdb-5716-834e-fbc26e4fd363
DOI: 10.1101/2022.07.14.500157

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