Article

Correspondence between functional scores from deep mutational scans and predicted effects on protein stability

2023-02-04

Abstract excerpt

Many methodologically diverse computational methods have been applied to the growing challenge of predicting and interpreting the effects of protein variants. As many pathogenic mutations have a perturbing effect on protein stability or intermolecular interactions, one highly interpretable approach is to use protein structural information to model the physical impacts of variants and predict their likely effects o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 122799b5-bba7-5bdc-b832-70eeeed57403
DOI: 10.1101/2023.02.03.527007

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Correspondence between functional scores from deep mutational scans and predicted effects on protein stabilityDOI 10.1101/2023.02.03.527007Read

Correspondence between functional scores from deep mutational scans and predicted effects on protein stability.Semantic proximity Read

Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation.Semantic proximity Read

Identification of pathogenic missense mutations using protein stability predictorsSemantic proximity Read

Rapid protein stability prediction using deep learning representationsSemantic proximity Read

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset.Semantic proximity Read

Identification of pathogenic missense mutations using protein stability predictors.Semantic proximity Read

Towards predictive biophysical and mechanistic models for disease-causing protein variantsSemantic proximity Read

Combining structural modeling with ensemble machine learning to accurately predict protein fold stability and binding affinity effects upon mutation.Semantic proximity Read

Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effectsSemantic proximity Read

RosettaDDGPrediction for high-throughput mutational scans: from stability to bindingSemantic proximity Read

PremPS: Predicting the Effects of Single Mutations on Protein StabilitySemantic proximity Read

Validating folding energy estimates as a method for variant interpretationSemantic proximity Read