Article

The Platelet-activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and its Experimental Inhibition by Rupatadine

2021-06-09

Abstract excerpt

The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development. In this study, we aimed to evaluate the prognostic value of PAFR in epithelial ovarian cancer (EOC) and the potential use of its antagonist, Rupatadine as an experimental treatment. Tissue microarrays of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dfc3e257-0db0-5ffa-9a81-52277f3d5a2d
DOI: 10.21203/rs.3.rs-589677/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

The Platelet-activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and its Experimental Inhibition by RupatadineDOI 10.21203/rs.3.rs-589677/v1Read

Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium.Semantic proximity Read

p38MAPK family isoform p38α and activating transcription factor 2 are associated with the malignant phenotypes and poor prognosis of patients with ovarian adenocarcinoma.Semantic proximity Read

Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients.Semantic proximity Read

Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progressionSemantic proximity Read

Knockdown CD44 Promotes Amyloid-Beta Degradation in Ovarian Cancer Cells By Regulating CD36 ExpressionSemantic proximity Read

Lysophosphatidic acid receptors in cancer pathobiology.Semantic proximity Read

Modulation of Tumor-Associated Macrophages (TAM) Phenotype by Platelet-Activating Factor (PAF) Receptor.Semantic proximity Read

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasionSemantic proximity Read

mPRα mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway.Semantic proximity Read

Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer.Semantic proximity Read

Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancerSemantic proximity Read