Article
Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients.
PloS one - 1 Jan 2012
Jacob Francis, Ukegjini Kristjan, Nixdorf Sheri, Ford Caroline E, Olivier Jake, Caduff Rosmarie, Scurry James P, Guertler Rea, Hornung Daniela, Mueller Renato, Fink Daniel A, Hacker Neville F, Heinzelmann-Schwarz Viola A
Abstract excerpt
BACKGROUND: Activation of the Wnt signaling pathway is implicated in aberrant cellular proliferation in various cancers. In 40% of endometrioid ovarian cancers, constitutive activation of the pathway is due to oncogenic mutations in β-catenin or other inactivating mutations in key negative regulators. Secreted frizzled-related protein 4 (SFRP4) has been proposed to have inhibitory activity through binding and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.