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mPRα mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway.

Molecular carcinogenesis - 1 Feb 2020

Lu Xiaoxiao, Guan Anqi, Chen Xi, Xiao Jian, Xie Mingxuan, Yang Baishuang, He Shuya, You Shaojin, Li Wei, Chen Qiong

Abstract excerpt

The discovery of epidermal growth factor receptor (EGFR) mutations has made EGFR tyrosine kinase inhibitors (EGFR-TKIs) a milestone in the treatment for advanced non-small cell lung cancer (NSCLC). However, patients lacking EGFR mutations are not sensitive to EGFR-TKI treatment and the emergence of secondary resistance poses new challenges for the targeted therapy of lung cancer. In this study, we identified that...

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PMID: 31777985
DOI: 10.1002/mc.23139

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