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Article

Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer.

PloS one - 1 Jan 2015

Isobe Aki, Sawada Kenjiro, Kinose Yasuto, Ohyagi-Hara Chifumi, Nakatsuka Erika, Makino Hiroshi, Ogura Tomonori, Mizuno Tomoko, Suzuki Noriko, Morii Eiichi, Nakamura Koji, Sawada Ikuko, Toda Aska, Hashimoto Kae, Mabuchi Seiji, Ohta Tsuyoshi, Morishige Ken-ichirou, Kurachi Hirohisa, Kimura Tadashi

Abstract excerpt

Ovarian cancer remains the most lethal gynecologic cancer and new targeted molecular therapies against this miserable disease continue to be challenging. In this study, we analyzed the expressional patterns of Interleukin-6 (IL-6) and its receptor (IL-6R) expression in ovarian cancer tissues, evaluated the impact of these expressions on clinical outcomes of patients, and found that a high-level of IL-6R...

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Identifiers

PMID: 25658637
DOI: 10.1371/journal.pone.0118080
PMCID: PMC4319819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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