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Article

Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression

26 Aug 2019

Abstract excerpt

BACKGROUND: Recent clinical trials on ovarian cancer with mifepristone (MF) have failed, despite in vitro findings on its strong progesterone (P4) antagonist function. METHODS: Ovarian cancer human and murine cell lines, cultured high-grade human primary epithelial ovarian cancer (HG-hOEC) cells and their explants; as well as in vivo transgenic mice possessing ovarian cancer were used to assess the molecular...

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PMID: 31466918
DOI: 10.1016/j.ebiom.2019.08.035

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