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Article

Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium.

Reproductive biology and endocrinology : RB&E - 24 Jun 2010

Zhang Lifang, Wang Dan, Jiang Wei, Edwards Dale, Qiu Weiliang, Barroilhet Lisa M, Rho Jung-Hyun, Jin Lianjin, Seethappan Vanitha, Vitonis Allison, Wang Jianliu, Mok Samuel C, Crum Christopher, Cramer Daniel W, Ye Bin

Abstract excerpt

OBJECTIVES: It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular targets and pathways involved in early malignant transformation are still not clear. Pro-inflammatory lipids and pathways have been reported to play significant roles in ovarian cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20576130
DOI: 10.1186/1477-7827-8-74
PMCID: PMC2903602

Genes

BRCA1
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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