Article

Hepatocyte-, but not myeloid cell- Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet

2026-06-18

Abstract excerpt

Previous studies have demonstrated that mechanistic target of rapamycin complex 2 (mTORC2) deficiency provides complete protection against steatotic liver disease driven by constitutive activation of the phosphoinositide 3-kinase (PI3K)–Akt signaling pathway and de novo lipogenesis, and partial protection against disease induced by a high-fat diet. We investigated herein whether mTORC2 deficiency in hepatocytes an...

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Literature Corpus work: 7b7dab3c-04bd-5243-a81d-e89ca2dc68ef
DOI: 10.64898/2026.06.17.732842

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Hepatocyte-, but not myeloid cell- Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat dietDOI 10.64898/2026.06.17.732842Read

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