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Article

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins.

Cells - 29 Nov 2019

Inoue Masa-Ki, Nakatsu Yusuke, Yamamotoya Takeshi, Hasei Shun, Kanamoto Mayu, Naitou Miki, Matsunaga Yasuka, Sakoda Hideyuki, Fujishiro Midori, Ono Hiraku, Kushiyama Akifumi, Asano Tomoichiro

Abstract excerpt

Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompanying inflammation. Indeed, Pin1-deficient mice are highly resistant to non-alcoholic steatohepatitis (NASH) development by either a high-fat diet or methionine-choline-deficient...

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Identifiers

PMID: 31795496
DOI: 10.3390/cells8121545
PMCID: PMC6952946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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