Article
Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.
Circulation - 26 Jul 2016
Tang Soon Yew, Monslow James, R Grant Gregory, Todd Leslie, Pawelzik Sven-Christian, Chen Lihong, Lawson John, Puré Ellen, FitzGerald Garret A
Abstract excerpt
BACKGROUND: Inhibitors of cyclooxygenase-2 alleviate pain and reduce fever and inflammation by suppressing the biosynthesis of prostacyclin (PGI2) and prostaglandin E2. However, suppression of these prostaglandins, particularly PGI2, by cyclooxygenase-2 inhibition or deletion of its I prostanoid receptor also predisposes to accelerated atherogenesis and thrombosis in mice. By contrast, deletion of microsomal...
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