Article

Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN

2018-06-28

Abstract excerpt

Inhibition of the tumour promoting activities of NF-κB by cell signalling pathways has been proposed as a natural mechanism to limit the development of cancer. However, there has been a lack of evidence for these effects in vivo . Here we report that RelA T505A mice, where a CHK1 targeted Thr505 phosphosite is mutated to alanine, display earlier onset of MYC driven lymphoma than wild type littermates. We describ...

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Literature Corpus work: df9da5ea-d256-59b7-95ca-86f73546a2da
DOI: 10.1101/358291

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