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Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

24 Aug 2020

Abstract excerpt

Claspin is a multifunctional protein that participates in physiological processes essential for cell homeostasis that are often defective in cancer, namely due to genetic changes. It is conceivable that Claspin gene (CLSPN) alterations may contribute to cancer development. Therefore, CLSPN germline alterations were characterized in sporadic and familial breast cancer and glioma samples, as well as in six cancer...

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PMID: 32847043
DOI: 10.3390/cancers12092396

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