Article

TTC22 promotes m6A-mediated WTAP expression and colon cancer metastasis in an RPL4 binding-dependent pattern

2022-07-05

Abstract excerpt

<title>Abstract</title> <p>WTAP, an essential component of the RNA N-6-methyladenosine (m6A) modification complex, guides METLL3-METLL14 heteroduplexes to target RNAs in the nuclear speckles of mammalian cells. Here, we show that <italic>TTC22</italic> is widely coexpressed with <italic>WTAP</italic> and <italic>FTO</italic> in many human tissues by mining Genotype-Tissue Expression (GTEx) datasets. Our results i...

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Literature Corpus work: df863ec7-2a10-514a-8e17-a15d13b50390
DOI: 10.21203/rs.3.rs-1278091/v1

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