Article

WTAP, transcriptionally regulated by p65, promotes inflammation through m <sup>6</sup> A modification and phase separation

2023-11-02

Abstract excerpt

Emerging evidence has linked dysregulation of N 6 -methyladenosine (m 6 A) to inflammation and inflammatory diseases, but the underlying mechanism still needs investigation. Here, we found that high m 6 A modification in a variety of hyperinflammatory states is p65-dependent, because Wilms tumor 1 associated protein (WTAP), a key component of the writer complex, is transcriptionally regulated by p65 and its ove...

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Literature Corpus work: e0f5c22b-46e3-5c77-a442-640b834c256e
DOI: 10.1101/2023.10.30.564747

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