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Article

CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.

Nucleic acids research - 19 May 2015

Steckelberg Anna-Lena, Altmueller Janine, Dieterich Christoph, Gehring Niels H

Abstract excerpt

In metazoan cells, spliced mRNAs are marked by the exon junction complex (EJC), a multi-protein complex that serves as a key regulator of post-transcriptional mRNA metabolism. Deposition of EJCs on mRNA is intimately linked to the splicing process. The spliceosomal protein CWC22 directly binds the core EJC-protein eIF4A3, guides it to the spliceosome and initiates EJC assembly. In addition, CWC22 is involved in...

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Identifiers

PMID: 25870412
DOI: 10.1093/nar/gkv320
PMCID: PMC4482076

Genes

CWC22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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