Article

Inhibition of <i>N</i> -myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells

2021-06-22

Abstract excerpt

<h4>SUMMARY</h4> Naive and primed states are distinct states of pluripotency during early embryonic development that can be captured and converted to each other in vitro . To elucidate the regulatory mechanism of pluripotency, we performed a recessive genetic screen of homozygous mutant mouse embryonic stem cells (mESCs) and found that suppression of N -myristoyltransferase (Nmt) promotes naive pluripotency. Di...

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Literature Corpus work: df820ed3-54f1-5711-a679-a6d7d3311039
DOI: 10.1101/2021.06.22.449326

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Inhibition of <i>N</i> -myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem CellsDOI 10.1101/2021.06.22.449326Read

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