Article

Evidence that APP gene copy number changes reflect recombinant vector contamination

2019-07-22

Abstract excerpt

Mutations that occur in cells of the body, called somatic mutations, cause human diseases including cancer and some neurological disorders 1 . In a recent study published in Nature, Lee et al. 2 (hereafter “the Lee study”) reported somatic copy number gains of the APP gene, a known risk locus of Alzheimer’s disease (AD), in the neurons of AD-patients and controls (69% vs 25% of neurons with at least one APP c...

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Literature Corpus work: df59cb78-0ddb-532e-9bc3-650a35e4f448
DOI: 10.1101/706788

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