Article

Detection of APP gene recombinant in human blood plasma

2023-06-09

Abstract excerpt

The pathogenesis of Alzheimer's disease (AD) is believed to involve the accumulation of amyloid-β in the brain, which is produced by the sequential cleavage of amyloid precursor protein (APP) by β-secretase and γ-secretase. Recently, analysis of genomic DNA and mRNA from postmortem brain neurons has revealed intra-exonic recombinants of APP (gencDNA), which have been implicated in the accumulation of amyloid-β. In...

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Literature Corpus work: cbbc4561-a982-54a8-9609-c56c1e5cbace
DOI: 10.21203/rs.3.rs-3007766/v1

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