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Article

Role of common and rare APP DNA sequence variants in Alzheimer disease.

Neurology - 17 Apr 2012

Hooli B V, Mohapatra G, Mattheisen M, Parrado A R, Roehr J T, Shen Y, Gusella J F, Moir R, Saunders A J, Lange C, Tanzi R E, Bertram L

Abstract excerpt

OBJECTIVES: More than 30 different rare mutations, including copy number variants (CNVs), in the amyloid precursor protein gene (APP) cause early-onset familial Alzheimer disease (EOFAD), whereas the contribution of common APP variants to disease risk remains controversial. In this study we systematically assessed the role of both rare and common APP DNA variants in Alzheimer disease (AD) families. METHODS:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22491860
DOI: 10.1212/WNL.0b013e3182515972
PMCID: PMC3324321

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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