Article

Reply: Evidence that <i>APP</i> gene copy number changes reflect recombinant vector contamination

2019-08-13

Abstract excerpt

In the accompanying comment 1 , Kim et al . concluded that somatic gene recombination ( SGR ) and amyloid precursor protein ( APP ) genomic complementary DNAs ( gencDNAs ) in brain are contamination artifacts and do not naturally exist. We disagree. Here we address the three types of analyses used by Kim et al . to reach their conclusions: informatic contaminant identification, plasmid PCR, and single-cell s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 951ceb2d-1dc3-5f3d-b0a0-10d924861c86
DOI: 10.1101/730291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reply: Evidence that <i>APP</i> gene copy number changes reflect recombinant vector contaminationDOI 10.1101/730291Read

Evidence that APP gene copy number changes reflect recombinant vector contaminationSemantic proximity Read

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cellsSemantic proximity Read

Alzheimer’s Disease risk modifier genes do not impact tau aggregate uptake, seeding or maintenance in cell modelsSemantic proximity Read

Detection of APP gene recombinant in human blood plasmaSemantic proximity Read

When DNA gets in the way in RNA-seq experiments, a sequelSemantic proximity Read

A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer diseaseSemantic proximity Read

Transcript errors generate amyloid-like proteins in huwman cells.Semantic proximity Read

Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series.Semantic proximity Read

Bacterial DNA promotes Tau aggregationSemantic proximity Read

Transfection "Junk" DNA - a link to the pathogenesis of Alzheimer's disease?Semantic proximity Read

Conclusive demonstration of iatrogenic Alzheimer’s disease transmission in a model of stem cell transplantationSemantic proximity Read

Prion Seeding Activity in DNA Extractions: Implications for Laboratory BiosafetySemantic proximity Read