Article

MDA5 variants trade antiviral activity for protection from autoimmune disease

2024-10-04

Abstract excerpt

Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studies (GWAS). MDA5 loss-of-function variants have also been reported to increase the risk of inflammatory bowel disease (IBD). Whether these associations are linked or extend to other diseases remains unclear. Here, fine-...

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Literature Corpus work: df454251-bc34-592e-b653-ae34ffb0b6ab
DOI: 10.1101/2024.10.04.24314884

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