MDA5 variants trade antiviral activity for protection from autoimmune disease.

Abstract excerpt

Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studies (GWAS). MDA5 loss-of-function variants have also been reported to increase the risk of inflammatory bowel disease (IBD). Whether these associations are linked or extend to other diseases remains unclear. Here,...

Topics

• Interferon-Induced Helicase, IFIH1
• Humans
• Genome-Wide Association Study
• Autoimmune Diseases
• Polymorphism, Single Nucleotide
• Diabetes Mellitus, Type 1