Article
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
Immunity - 20 Feb 2014
Funabiki Masahide, Kato Hiroki, Miyachi Yoshiki, Toki Hideaki, Motegi Hiromi, Inoue Maki, Minowa Osamu, Yoshida Aiko, Deguchi Katashi, Sato Hiroshi, Ito Sadayoshi, Shiroishi Toshihiko, Takeyasu Kunio, Noda Tetsuo, Fujita Takashi
Abstract excerpt
MDA5 is an essential intracellular sensor for several viruses, including picornaviruses, and elicits antiviral interferon (IFN) responses by recognizing viral dsRNAs. MDA5 has been implicated in autoimmunity. However, the mechanisms of how MDA5 contributes to autoimmunity remain unclear. Here we provide direct evidence that dysregulation of MDA5 caused autoimmune disorders. We established a mutant mouse line...
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