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Article

mTORC1 hyperactivation causes sensory integration deficits due to habenula impairment

2022-07-21

Abstract excerpt

Mechanistic target of rapamycin complex 1 (mTORC1) is an integration hub for extracellular and intracellular signals necessary for proper brain development. Hyperactivation of mTORC1 is found in many developmental diseases, including autism spectrum disorder (ASD). Atypical reactivity to sensory stimuli is often found in patients with ASD. The most frequent hereditary cause of ASD is Tuberous Sclerosis Complex (TS...

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Literature Corpus work
df29ef7f-0c45-5ab6-828a-2d3a5c3fbe84
DOI
10.1101/2022.07.20.500762
Open publication

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mTORC1 hyperactivation causes sensory integration deficits due to habenula impairmentDOI 10.1101/2022.07.20.500762
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